Postorgasmic illness syndrome (POIS) is a rare condition in which a man develops flu-like symptoms after ejaculation. Specific symptoms can include extreme fatigue, weakness, feverishness or sweating, mood changes or irritability, memory or concentration problems, and/or a stuffy nose or itching eyes. Symptoms may occur within seconds, minutes, or a few hours after ejaculation. Most symptoms last for 2 to 7 days and go away on their own.
Additional symptoms include intense discomfort, irritability, anxiety, craving for relief, susceptibility to nervous system stresses (e.g. common cold), depressed mood, and difficulty communicating, remembering words, reading and retaining information, concentrating, and socializing. Affected individuals may also experience intense warmth or cold.
The symptoms begin shortly after or within a half hour of ejaculation. The symptoms can last for several days, sometimes up to a week.